Lovely hot donuts! I do actually think it's an interesting point. If we take nationality as country the player has represented or would choose to represent then it might be the first time it's ever happened. (As for Akpan, he was born in Liverpool and not played for anyone but expressed his interest in playing for Nigeria)
However, there has been a rapid decline in the number of English players in the Reading team since the last time we were in the Premiership. If you think about the team that won the championship in 2005/06, there was six "english" players (Shorey, Harper, Sidwell, Little, Kitson, Lita) that were in the starting XI fairly regularly. (This number however is diminished by how little the team was changed around. This is six from 15 players who regularly played as opposed to the twenty-something in other years).
In the 2006/07 season there was really only five who were involved regularly due to Kitson spending most of the season out with injury. Also Dubbery was involved in a handful of games towards the end of the season but not enough to describe him as regular.
In 2007/08 we were back up to six "english" regulars (Shorey, Rosenior, Dubbery, Harper, Kitson, Lita).
In 2008/09 though we had a drop down to just three/ four (Dubbery, Rosenior, Harper and possibly Armstrong who played for both England U20s and Scotland B)
In 2009/10 it was up to four (Bertand, Griffin, Mills and Howard who wanted to play for Scotland but was sort of ineligible (
http://en.wikipedia.org/wiki/Brian_Howard_(footballer)#International_career) and had played for England at youth level)
In 2010/11 it was just three (Griffin, Mills, Howard)
Last season it was still three (Cummings, J. Mills, Le Fondre)
This season, however, there has been just the one (Shorey).
So, as much as everyone else has been dismissive, I do think it's an interesting trend. I've skimmed through line-ups of the last few years and I think this could be the first time it's happened but as you can see, this point has been inevitable.
NB: I've classed "regular" as having started at least a third of games.